Ph. D. in Biological Engineering, 2014
Massachusetts Institute of Technology, Cambridge MA

B. S. in Biochemistry and B. A. in Economics, 2008
Case Western Reserve University, Cleveland OH
Minor in Chemistry; graduated summa cum laude with 4.0 GPA

Ayersville High School, Defiance OH
Graduated valedictorian with 4.0 GPA


Career History

Principal Software Engineer, Applied BioMath, June 2017-present
Associate Principal Scientist, Merck, May 2017-June 2017
Senior Scientist, Merck, July 2014-May 2017
Graduate Researcher, Bruce Tidor lab, Massachusetts Institute of Technology, 2009-2014
Teaching Assistant, Biological Engineering Department, Massachusetts Institute of Technology, 2009
Undergraduate Researcher, Richard W Hanson lab, Case Western Reserve University, 2005-2008


Rajesh Krishna, Ferdous Gheyas, Yang Liu, David R Hagen, Brittany Walker, Akshita Chawla, Josee Cote, Robert O Blaustein, David E Gutstein, “Chronic Administration of Anacetrapib Is Associated With Accumulation in Adipose and Slow Elimination“, Clinical Pharmacology and Therapeutics, 2017.

David R Hagen and Bruce Tidor, “A Computational Experimental Design Method for Efficiently Reducing Topology Uncertainty”, unsubmitted.

David R Hagen and Bruce Tidor, “Efficient Bayesian Estimates for Discrimination among Topologically Different Systems Biology Models“, Molecular BioSystems, 2015.

David R Hagen, “Parameter and Topology Uncertainty for Optimal Experimental Design“, MIT Doctoral Thesis, 2014.

David R Hagen, Jacob K White, and Bruce Tidor, “Convergence in parameters and predictions using computational experimental design“, Interface Focus, 2013.

David R Hagen, Joshua F Apgar, David K Witmer, Forest M White, Bruce Tidor, “Reply to Comment on ‘Sloppy models, parameter uncertainty, and the role of experimental design’“, Molecular BioSystems, 2011.

Parvin Hakimi, Jianqi Yang, Gemma Casadesus, Duna Massillon, Fatima Tolentino-Silva, Colleen K Nye, Marco E Cabrera, David R Hagen, Christopher B Utter, Yacoub Baghdy, David H Johnson, David L Wilson, John P Kirwan, Satish C Kalhan, Richard W Hanson, “Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse“, Journal of Biological Chemistry, 2007.

Invited Talks

David R Hagen, “Know what You Know”, ICBP MIT, 2013.

David R Hagen, “If at First you Don’t Succeed, Try Experimental Design”, ICBP Mathematics, 2012.

David R Hagen, “If at First you Don’t Succeed, Try Experimental Design”, IEEE EMBC, 2011.

David R Hagen, “PEPCK-C over-expression in muscle repatterns energy metabolism in mice”, Diabetes Association of Greater Cleveland, 2007.